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KMID : 0370220030470040200
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Yakhak Hoeji
2003 Volume.47 No. 4 p.200 ~ p.205
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Determination of Stability Constants for β-Blocker and Carboxymethyl-β-cyclodextrin Complexes by Capillary Electrophoresis
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박경래
임환미/뉴엔티퐁/김경호/강종성
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Abstract
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The stability constants for the inclusion complexes between carboxymethyl-β- cyclodextrin (CM-β-CD) and five β-blockers, such as atenolol (ATE), bisoprolol (BIS), metoprolol (MET), pindolol (PIN) and propranolol (PRO) were determined by capillary electrophoresis. The magnitude of stability was decreased as following order; PRO>MET>BIS> ATE>PIN. Among them PRO showed the highest affinity towards CM-β- CD with stability constants of 383 and 371 M-1 for (R)- and (S)-enantiomer respectively: PIN enantiomers showed the lowest stability towards CM-β-CD, while the selectivity between (R)- and (S)-enantiomer was higher than any other tested β- blocker.
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KEYWORD
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